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Nine words put O first and S third. OASIS and ONSET are the two you would reach for and the rest need a dictionary.
O is an uncommon opening letter and an S in the third box does not follow it easily. Nine words is what English leaves, spread across six different second letters.
A leads that box on three words and U follows on two. Every other letter appears exactly once, so the second box eliminates almost nothing.
ONSET and OASIS are the practical answers. OUSTS is reachable if you think of the verb. OPSIN, OSSIA, OUSEL and OWSEN are all real and all unlikely.
OASES, OASIS and OASTS share their first three letters, so the A branch is one stem rather than three ideas. OASES is the plural of OASIS, which means guessing one when the other is the answer costs a full turn.
S closes four of the nine, forty four percent, and nothing else reaches more than two.
E and I take seven of the fourth box between them. Those two facts together describe almost everything this page does.
OASIS is singular and OASES is plural, and both are on this list. The fourth box separates them, so confirm it before guessing either.
A variant spelling of ouzel, a type of bird. It sits in the U branch with OUSTS and neither is a word you would guess first.
Yes, it runs O, N, S, E, T. The N in the second box is the only one on the page, which makes ONSET easy to confirm or eliminate.