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Seventy three words begin with Z, and the second box is a vowel in nearly all of them.
O takes the second box in twenty two of the seventy three, thirty percent, and I takes twenty. A takes thirteen and E takes eleven. Only seven letters appear there and the handful that are not vowels hold three words between them.
ZEBRA, ZESTY, ZONAL and ZIPPY are the entries most people would produce, with ZEROS and ZINGS behind them.
That is a very short core for a page of seventy three. Most of what remains arrived from other languages and would not occur to you during a puzzle.
Z appears less than any other letter in ordinary English, so a Z guess that misses confirms something you already suspected. It works as a confirmation, not as an exploration.
N takes the third box in sixteen words, twenty two percent, more than any other letter. If you are committed to the page, that is the branch to test.
S closes twenty one of the seventy three, twenty nine percent, far ahead of anything else. Eleven words repeat a letter, which is fifteen percent, so a visible double narrows things usefully.
It is the most recognisable word here and it tests E in the second box, which eleven words take.
Z is rare at the front of English words, so most of the seventy three came in from other languages. The core vocabulary is a dozen entries at most.
Twenty one, which is twenty nine percent. Nothing else reaches more than eight.