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Five hundred forty one words begin with M, and two vowels take more than half the second box between them.
A follows the M in one hundred fifty six words, twenty nine percent, and O in one hundred twenty nine. I takes ninety five, E takes seventy four and U takes seventy one. Together A and O cover two hundred eighty five of the five hundred forty one.
MONEY, MUSIC, MIGHT, MAJOR and MOTOR are the entries a puzzle is most likely to want, with MEDIA, MOUTH and MAGIC behind them.
Only ten letters appear in that box across all five hundred forty one words, and apart from a Y branch of twelve and two stray entries, every one is a vowel.
That is a strong narrowing to know before you guess. It rules out the consonant blends that work on most other opening letters.
E fills the fourth box in one hundred one of the five hundred forty one, nineteen percent, and S closes one hundred fifty six, twenty nine percent. Y takes another eighty at the end.
MONEY tests the O branch, the E fourth box and the Y ending in one turn, which makes it unusually efficient as an opening word here.
A, on one hundred fifty six words. It is the single best bet at twenty nine percent, though O on one hundred twenty nine is close enough to stay live.
Barely. Only ten letters appear in that box and nearly all are vowels, so a consonant guess there is close to wasted.
One hundred fifty six, which is twenty nine percent. Y follows on eighty, so those two take most of the last box.