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128 five letter words start with TR, and every one of them puts a vowel in the third box.
I takes about twenty five percent, O twenty four and A twenty two. E and U take thirteen each, and Y picks up the small remainder.
Three branches within three points of each other, and the other two are not far behind. Very few openings divide this evenly.
That means the third box rarely settles the word on its own, so the useful move is a guess whose last two letters cover common endings.
TRACK, TRADE and TRIAL between them test C, K, D, E, A and L, which is most of what those final boxes hold.
TRIED, TRIES and TRIPS all sit on the I branch and share their first three letters, which is the tightest family on the page.
TRAIN is the best single opener. It covers the A branch and its I and N reach two more, so a partial hit still tells you a great deal.
TR is already a two consonant blend, and English does not stack a third at the start of a word. A vowel has to follow it.
They share four letters and differ in the last box, so either settles the other. TRUST is the more common of the two.
The U branch. TRUST, TRUTH and TRUCK lead it, but below those it thins out faster than the I, O or A branches.