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Three hundred eighty one words begin with H, and the second box is a vowel in all but one of them.
A takes the second box in one hundred fifteen of the three hundred eighty one, thirty percent, with O on one hundred and E on seventy six. I, U and Y share what is left.
HEART, HOUSE, HAPPY, HORSE and HOTEL are the entries a puzzle is most likely to want. HUMAN, HONEY and HEAVY follow, and all of them sit in the three main branches.
Only six letters appear in that box across all three hundred eighty one words, and every one of them is a vowel or a Y apart from a single entry.
So the second box is a vowel choice and nothing more. That is a strong narrowing if you use it, because it rules out most instinctive consonant guesses before you make them.
S closes one hundred twenty eight of the three hundred eighty one, thirty four percent, which is the highest share of any letter on this page. E fills the fourth box in eighty three words, twenty two percent.
Both are common and they test different vowels. HOUSE also covers the E fourth box and the S ending, which between them describe most of the page.
Almost never. One entry on the whole page does it, so for practical purposes the second box is a vowel.
One hundred twenty eight, which is thirty four percent. Y follows on fifty six, so those two take nearly half the last box.