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1196 five letter words start with C, and nearly half of them take O or A as the second letter.
O leads at about twenty four percent and A follows at twenty one. H takes sixteen, which is high for a consonant, and R, L and U share most of what is left.
CH is the one branch where the two letters make a single sound rather than a blend you can hear separately. CHECK, CHILD, CHEAP and CHAIR all sit there.
That matters when you are reading letters aloud to yourself, because the H disappears into the sound and is easy to leave out of your guess.
CR and CL carry another nineteen percent between them, with CROSS, CLEAR, CLOSE and CLASS among the commonest.
CU is smaller and thinner, so if O, A and H have all failed, CR and CL are the branches worth testing before anything else.
C is unusual in that its two biggest branches lead to completely different kinds of word. CO tends toward nouns like COURT and COLOR, while CL and CR lean on verbs.
CHAIR covers the H branch and tests A, I and R. CLASS repeats its S, which wastes a box, so CHAIR gives you more back.
CLICK, CHECK and BLOCK style words are built on a short vowel followed by CK, and C words reach that shape more often than most.
Rarely. CE and CI openings exist but they are a small slice, which is why the three vowel branches you would expect are really only three.