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Sixty four words put P first and L third, and the vowels sit within a handful of words of each other in the second box.
A takes the second box in sixteen of the sixty four, I in fifteen, O in fourteen and U in twelve. E adds five more and only two words use anything else.
That flatness means a guess in the second box removes roughly a quarter of the page at best. The fourth box does better, with E taking eighteen words, twenty eight percent.
Eight words repeat a letter and most double the L. PALLA, PALLY, PALLS, PILLS, POLLY and POLLS all do it, and each sits one vowel from another.
PILOT, POLAR, POLIO, POLKA and PALSY are the ordinary words that avoid the double entirely. They spread across different endings, which makes any of them a better opening than a doubled L guess.
S closes twenty two of the sixty four, thirty four percent, well ahead of Y on seven. Ruling out a plural is the single biggest cut available on this page.
It is the most common word here and it avoids the doubled L branch, so it tells you more per turn than PILLS or POLLS would.
A large flat floored depression in limestone country. It is the only word here ending in JE and one of the least reachable entries.
They are variant spellings of the same rice dish, and PILAF is a third. All three sit in the I branch.