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One hundred sixty one words put S first and I third, which makes this one of the largest patterns in the family. The second box stays open for a long time.
P takes the second box in twenty nine of the one hundred sixty one, with H on twenty three, T on twenty two and K on twenty one. L, W and N follow in the teens.
That is a lot of branches sitting close together. A guess in the second box removes only a modest slice, which is real progress but nowhere near decisive on a page this size.
Most players reach for SHINE, SLICE, SPINE or STILL. SUITE uses a U in the second box where almost nothing else does, so it either wins outright or eliminates a branch nobody else would have checked.
S and E close seventy of the one hundred sixty one between them, twenty two percent for S alone. N leads the fourth box on twenty four words. Those two facts describe most of the page, and neither helps you separate SHINS from SKINS or SHIRT from SKIRT.
The last box. S and E take seventy of the one hundred sixty one between them, which is a bigger cut than any second letter can offer.
One box, and both are everyday words. SHIRR and SKIRR do the same thing nearby, so that corner of the page is full of traps.
Thirteen do, mostly the doubled L of SKILL, SHILL and SPILL. It is a modest share for a page of one hundred sixty one, so a double narrows usefully.