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Just two words put S second and Y third, and they have nothing in common beyond those letters.
PSYCH is the informal verb and noun from psychology, as in psych yourself up. ASYLA is the Latin plural of asylum, used mainly in academic and historical writing.
The P in PSYCH is not pronounced, following the Greek words English borrowed it from. ASYLA is said exactly as it looks, which makes the two entries behave differently the moment you try to reason from sound.
A opens one and P the other, and the fourth and last boxes take a different letter in each. Every box on this page is a straight two way choice.
Yes, it is established in dictionaries as both noun and verb. Psych out and psych up are the commonest uses.
Both plurals exist. ASYLUMS is the ordinary English form and ASYLA the Latin one, which survives in formal writing about institutions.
PSYCH, since it is far commoner in general English. ASYLA would be an unusual choice for a setter.
It comes from Greek psyche, where the P was pronounced. English kept the spelling and dropped the sound.
Zero of the two do, and no box shares a letter with another.