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Seventeen words put E first and A third. X is unusually well represented in the second box, which is the most useful thing to know here.
EMAIL is the one word in this group you would use in an ordinary sentence. ENACT, ERASE, EVADE and EXACT follow, taking N, R, V and X in the second box between them.
Nothing else here is close. Most of the remaining words are either technical or archaic, so if EMAIL fits the other constraints it is almost always the right first guess.
X takes the second box in three of seventeen words, eighteen percent. On most pages X is a throwaway letter. Here it is among the most common things in that slot, which makes EXALT and EXAMS a genuinely sensible line to try.
ENACT, ERASE, EVADE and ELATE are all verbs, and each ends in a letter that nine of the group shares. If the puzzle wants a verb, this pattern supplies more of them than its size suggests.
Only one word in the whole group repeats a letter. On most patterns a doubled letter is worth a thought. Here it is close to a dead end.
One M and one L. It is the most common word on this pattern, so it is worth getting right before you spend a guess elsewhere.
Yes, and they differ only in the last box. EXAMS makes a third word on the same stem, so the EXA branch can absorb several turns if you let it.
E, S and T are almost level, on five, four and four. Between them they take thirteen of the seventeen, so the last box is nearly decided before you start.