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Only five words carry S second and C third, and every one of them opens with a vowel.
A and E each take two of the five, with O taking the last. No consonant will sit in front of an S and C at this length.
That narrows the first box to three options before you begin, which is more help than most small groups offer.
An ascot is a broad neck tie, and an oscar is a South American freshwater fish kept in aquariums as well as the name of the award. Both are ordinary nouns in their own right.
ASCUS, a spore sac in certain fungi, is the third entry with a settled meaning. ESCAR and ESCOT are variants of eschar and escheat and are rarely written at all now.
O and A each fill the fourth box in two of the five, with U taking the remaining one. T and R each close two of them.
ASCOT, since it is the entry a general reader is most likely to know. If the first letter comes back wrong, OSCAR is the obvious next move.
The sac in which spores develop in a group of fungi called ascomycetes. Its plural is asci.
A variant of eschar, the dry scab that forms over a burn. It is medical vocabulary with an unusual spelling.
An old legal term for a tax or payment, related to escheat. It has dropped out of use entirely.
SC is a cluster English puts at the front of words like SCAN and SCOPE. Pushed to the second and third boxes it needs a vowel ahead of it, and nothing else works.