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Seventy two words place O second and M third, and one pair of them is among the commonest in English.
Both are everyday words, both fit the pattern, and they differ in the fourth box alone. A puzzle using this pattern is likelier to want one of these than anything else on the page.
The vowel change is what marks singular from plural, which is unusual in English. It also means you cannot reason your way from one to the other.
C opens twenty of the seventy two, well ahead of everything else. COMES, COMET, COMIC, COMBO, COMMA and COMFY all sit there.
B takes it in fourteen of the seventy two, second only to E on nineteen. BOMBS, BOMBE, COMBS, COMBE, COMBO, TOMBS and WOMBS all use it, which is a lot for a letter that rarely sits inside a word.
S closes twenty two of the seventy two, a long way ahead of Y on eight. Most of those are plain plurals.
The doubled M words are worth noting separately. COMMA, COMMO, COMMY, MOMMA, MOMMY and TOMMY all carry it, and several close on Y as well.
COMIC sits in the busiest branch but repeats the C. HOMES tests the H, E and S and is the cleaner probe.
A short valley or hollow in a hillside, chiefly in southern England. It also appears as coomb.
To count or reckon, an archaic form. COMPO and COMPS sit beside it and are unrelated to it.
Momus was the Greek god of mockery and a mome is a fool. The two share a root in the idea of ridicule.