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Only ten words hold P second and U third, and every single one of them starts with S.
S opens ten of the ten, which is all of them. No other letter produces this pair at five letters, so the opening box is settled before you make a guess.
That is unusual even among small groups. Most pages leave the front of the word open and narrow at the back, and here it is exactly the other way round.
R takes the fourth box in three of the ten, giving SPURS, SPURT and SPURN. E and M take two each, giving SPUED, SPUES, SPUME and SPUMY.
The last box spreads across eight letters with almost no repetition. So once you know the fourth letter you are usually choosing between two or three words.
SPURS, SPURT, SPUNK and SPUDS are the entries in ordinary use. SPUTA, the plural of sputum, is the most technical thing here.
SPURS or SPURT, since the R branch is the largest and both words are common. Confirming the fourth letter as R covers a good share of the page.
Froth or foam, especially on the sea. SPUMY is the adjective and both appear here.
The plural of sputum, matter coughed up from the lungs. It is medical vocabulary.
Zero of the ten do, so a repeat can be ruled out across the whole group.