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Twenty four words carry M second and B third, and a cluster of them differ only in their opening vowel.
Each runs the same last four letters and changes only the first. AMBER is fossilised resin, an EMBER is a glowing coal, UMBER is a brown pigment and OMBER is a card game.
That is as tight a cluster as this site produces. Confirming everything after the first box still leaves you with a straight choice among vowels, and the pattern gives you nothing to break the tie.
E takes eight of the twenty four, A takes six and U takes six, with I and O behind them. Twenty four of the twenty four begin with a vowel, so the first box is always a short list.
AMBER, EMBED, EMBER, UMBRA and AMBLE are the entries in general use. AMBIT and IMBUE are worth knowing, and OMBRE turns up in colour and fashion writing.
OMBER is the card game and OMBRE is the graded colour effect, though both spellings have been used for both senses over time.
The fully shaded inner region of a shadow, used in astronomy. UMBER, the pigment, sits beside it and is unrelated.
Both appear here and both are accepted. EMBED is far commoner in modern writing.
To arch or bend something into a bow shape. It is archaic and survives mainly in word lists.
Zero of the twenty four manage it, so a repeated letter can be ruled out from the start.