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Fifty words put M first and T third, and three vowels sit within a word or two of each other in the second box.
E takes the second box in twelve of the fifty, giving METAL, METER, METRE, METRO, METED and METES. METER and METRE are the same word spelled two ways and both are on this list, which is worth knowing before you commit.
A and O tie at thirteen words each, just ahead of E on twelve. I takes six and U takes five. There is no leader worth chasing.
E fills the fourth box in seventeen of the fifty instead, thirty four percent, which is the strongest single fact here. MATED, MATES, MOTEL, MOTES, MUTED and MUTES all run through it.
S closes fifteen of the fifty, thirty percent, well ahead of R and O on five each. Eight words repeat a letter, mostly the doubled T of MATTE, MOTTO, MOTTE and MUTTS, so a visible double points at a clear corner of the page.
Both appear on this list, as do MITER and MITRE. They are spelling variants, so the fourth box decides which one your puzzle wants.
Yes. It is common, it avoids the crowded E fourth box and its CH ending appears on only a few entries here.
A sailor, from the French. It is one of the narrower A branch entries and not one you would reach for.