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G at two and U at three leaves one word standing, and it is the plural of a fever nobody catches any more.
An ague is a fever marked by shivering and chills, used historically for malaria and illnesses like it. AGUES is its plural and the only five letter word putting G second and U third.
The word has not vanished entirely. It still turns up in historical writing and period fiction, which is more than most single entry patterns can claim.
U after G is common enough in English, in GUARD, GUESS and GUILT. But those all put the pair at the front. Moving it to positions two and three needs a vowel in front, and A is the only one that works at this length.
A fever with cold shivering fits, once the usual word for malarial illness.
Rarely, and mostly in historical or literary contexts. You are likelier to meet it in a novel set two centuries ago than in conversation.
The GU pair wants to sit at the start of a word. Pushed to the second and third boxes it needs an A in front and a workable ending behind, and almost nothing fits.
It uses only common tiles, so it scores little. Its use is as somewhere to dump vowels when your rack is crowded.
In two syllables, AY gyoo. The G is hard and the final E is silent, which surprises readers who meet it in print first.