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Only eleven words carry N second and U third, and R follows the U in almost half of them.
R takes the fourth box in five of the eleven, a large share for a group this size. INURE, ENURE, INURN, KNURL and KNURS all run through it.
That makes the fourth letter the obvious first test. Nothing else appears there more than once.
SNUFF, SNUCK and SNUBS are the entries in general use, with INURE close behind. SNUGS and KNURL are recognisable but uncommon.
Both mean to accustom someone to something unpleasant, and both are valid. INURE is the commoner spelling by a wide margin.
They differ in the first box, which is the one place this pattern gives you no help. I opens four of the eleven and S opens four, so both branches stay live.
SNUCK tests the C and K without repeating. SNUFF doubles the F, which spends part of the guess.
A genus of flowering plants including elecampane. It is botanical vocabulary and not a likely answer.
To place ashes in an urn after cremation. It is formal and rare outside funeral writing.
A small ridge or bead, especially the milled edging on a knob or a coin. KNURS are knots in wood.
One does, and it is SNUFF with its double F.