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One hundred five words start with LA, and the fourth box is an E in over a third of them.
T takes the third box in twelve of the one hundred five, R in ten and M in nine. I and N take eight each and twenty one letters appear there in total.
LARGE, LABEL, LATER, LAUGH and LAYER are the entries a puzzle is most likely to want, with LABOR, LAPSE and LATCH behind them.
The leader takes only eleven percent, so a guess aimed there removes very little. The fourth box behaves differently.
E fills it in thirty six of the one hundred five, thirty four percent, which is the strongest fact on the page. LACED, LACER, LACES, LADED and LADEN all run through it.
That also explains the near duplicates. LACED, LACER and LACES differ only at the end, and LADED, LADEN and LADER mirror them exactly.
S closes twenty nine of the one hundred five, twenty eight percent, with R on thirteen, D on twelve and Y on eleven. Between them they take most of the last box.
Both are common and they differ in three boxes. LAUGH tests the GH shape, which almost nothing else here uses.
The E fourth box turns short stems into matched triples. LACED, LACER and LACES is the pattern and it repeats across several stems.
Five, which is five percent. That is low for a page this size, so a visible double narrows it well.