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150 five letter words start with SE, and R follows more often than any other letter by a clear margin.
R takes about eighteen percent, N twelve, a second E eight, and A, P and G between five and six.
SEEMS, SENSE, SEVEN, SERVE and SETUP are the most used entries, and they cover four different third letters.
SEEMS, SEEDS, SEEKS and SEALS style shapes put a second E straight after the first, which is eight percent of the group.
If an E comes back in the third box, those four are most of what is left, so the doubling is a cheap and decisive test.
SERVE covers the leading branch, but it repeats its E. SEATS tests the same R region while keeping five distinct letters, which makes it the better opener.
Not especially. It repeats both its S and its E, so it tests only three distinct letters and wastes two boxes.
SERUM, SERIF and SEARS among others. It is the largest branch and it holds a reasonable spread of everyday words.
It is one of the common exceptions, taking EI where most words take IE. Worth remembering because players often spell it the other way.