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One hundred six words take E in the second box and L in the third, which makes it one of the fuller patterns in this family.
B leads with twelve words and D follows with eleven. T, H, C, F and M sit behind them, and seventeen letters appear in that box in total. A guess aimed at the first box is usually a wasted turn here.
BELOW, DELTA, DELAY and RELAX each take a different fourth letter and none of them doubles the L. HELIX is the outlier worth remembering, since an X in the last box clears almost everything else at once.
Twenty nine words put a second L in the fourth box, twenty seven percent, and several differ only in the final letter. BELLS, BELLE and BELLY are three separate words off one stem, so landing in that branch narrows far less than it feels like it should.
Thirty seven of the one hundred six end in S, thirty five percent. Y takes fifteen and E takes nine.
Nine words end in LY, the adverb ending doing its usual work. With an L and a Y confirmed at the back, that small group is worth reading through before guessing again.
Yes, it runs C, E, L, L, O. So does CELLS, and the two differ only in the last box.
The X. Almost nothing else in this group ends that way, so guessing it either wins outright or clears a lot of ground.
They share their first three letters and part company from the fourth box on. Both are common, so the back half of the word decides it.