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Twenty words carry C in the second box and O in the third, and sixteen of them start with S.
SCORE, SCOPE, SCOUT, SCORN and SCOOP all sit in that branch and all are common. Sixteen of twenty is eighty percent, so S is the safe first assumption for the opening box.
ICONS and ACORN are the two outside the SC branch that most people would actually use. Three words open with A in total, and only one with I.
S finishes four of the twenty, more than any other letter, and E takes three. Past those the tails scatter so widely that no ending offers much of a shortcut. The fourth box tells the same story, with R, P and U tied on three each.
They differ by one letter. SCOOP is the more common of the two, so start there and keep SCOOT in reserve.
Yes. It runs A, C, O, R, N, so the C is second and the O is third. It is one of three words here opening with A.
The CO pairing needs something in front of it, and very few letters sit comfortably before a hard C. S does almost all the work and everything else is thin.
Both are here, and they differ from the fourth box on. That is where this pattern is usually decided.