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Five words put V first and P third, and realistically two of them are the ones you will ever need.
VAPOR and VIPER are the two that carry this group. A fills the second box in three of the five, with E and I taking one each. Guess VAPOR first. If the A comes back wrong, VIPER follows naturally and the two share nothing in the last two boxes.
V is uncommon to start with and strongly prefers a vowel straight after. Fixing P into the third box leaves almost nothing for the rest of the word to do.
Very few English roots survive both constraints at once, which is how a list this short happens. Most letters would give you dozens of options in the same shape.
Note that VAPOR here has no U. The spelling with a U runs to six letters, so it falls outside a five letter list entirely.
It has V first and P third, but at six letters it is outside a five letter list, so it never appears here.
In practical terms yes. Once VAPOR and VIPER are gone you are down to words most players would not recognise.
VAPID, and it shares its first two letters with VAPOR while ending nothing like it. If an A lands in the second box, those two are the pair to separate.