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L first and S third gives 34 words, and the spread across the box between them is almost perfectly even.
A takes about twenty one percent, then E, Y and U all at eighteen, I at fifteen and O at twelve.
Six branches inside nine points of each other is as level as it gets, so there is no vowel worth chasing on its own.
LISTS, LASER, LOSES, LASTS and LOSER are the entries in everyday use, and they cover four different branches between them.
That is the practical point here. The common words are scattered, so a guess should be picked for its other letters rather than for the branch it sits on.
Y is the surprise at eighteen percent, though the words it produces are technical terms rather than anything you would name unprompted.
LASER is the strongest opener, since its A, S, E and R are four of the most common letters in the language and it sits on the largest branch.
No. LOOSE puts O in the second box and O again in the third. The S lands fourth.
LISTS and LASTS both finish in TS, and LOSES and LOSER differ only in the last box. Those are the two pairs worth knowing.
Yes, L first and S third with a second S right after. LYSSA does the same, though LASSO is the one you are far more likely to need.