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Eighteen words carry C second and U third, and almost all of them share the same opening.
S opens sixteen of the eighteen, so the pattern is really SCU followed by two more letters. Only ACUTE and OCULI sit outside it.
ACUTE and SCUBA are the two most people know. SCULL, SCURF and SCUFF are ordinary enough, and SCUTE turns up regularly in writing about reptiles.
Nine letters appear in the fourth box, led by T and L on four each. Nothing dominates, so knowing the first three letters leaves plenty open.
The last box is no better, with ten letters across eighteen words. This is a pattern where the back half genuinely has to be worked out.
It is the most familiar word in the group and it opens with a vowel, which two of these eighteen do. Testing it also rules out the whole SCU branch in one move if it comes back wrong.
Yes. It began as an acronym but is now written as an ordinary word, and it fits C second and U third.
SCUTE is a bony plate on a reptile and SCUTA is a plural of scutum, a Roman shield. The final letter is the whole difference.
It is a clipped form of excuse written without the opening E. It pads this group without being a word you would guess.