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C first and N third gives 77 words, and just two vowels carry more than seventy percent of the group.
O takes about forty percent of the box between them and A takes thirty one. Together that is roughly seven words in ten.
U and I split most of the small remainder, so realistically you are choosing between two branches rather than four.
CONDO, CONES and CANON take the O branch while CANDY, CANAL and CANOE take the A. Both families are large enough that landing the vowel does most of your work.
CENTS is the main entry on the E branch and it behaves nothing like the rest, so it is the one to try when both big families have been ruled out.
CANON repeats the N across the third and fifth boxes, which is a shape worth remembering because so few entries here do it.
No. CRANE puts R in the second box and A in the third, with the N fourth. It is the word people most often expect to find here.
CON, since O leads A by nine points. But if you have already ruled out O elsewhere in the puzzle, CANDY covers the other big family straight away.
No. CLONE puts L in the second box and O in the third. The N lands fourth, one box later than this pattern allows.