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22 five letter words start with ES, and a second S or a T follows in more than half of them.
A second S and T lead at about twenty seven percent each, then C at fourteen, K at nine and B at five.
It is by a wide margin the most common entry, and ESTER is the only other one a player would be likely to name.
ESKER is a glacial ridge and ESTOP is a legal term. Beyond those the page runs to place names and obsolete forms.
Guess ESSAY and stop there in most cases. Its doubled S also confirms the largest shape on the page in the same turn.
If it misses, ESTER is the one remaining entry worth a guess before the page runs out.
Yes, it is a chemistry term for a compound formed from an acid and an alcohol. It is the second most common entry here.
ESS and EST are the only two openings that combine freely after ES. Everything else produces one or two words at most.
Two comfortably, four at a stretch. The count of 22 overstates the page more than most.